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In 1987, GLP-1 (736) was recognized as a physiological incretin in the studies of Kreymann et al

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Consider the clinical reason for using it, ingredient identity, dose, manufacturing quality, stability, storage, tolerance, cost and whether the product is producing a meaningful benefit

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Hakaru Hashimoto The first indication of an immunologic abnormality in this disease was an elevation of the plasma gamma globulin fraction detected by Fromm et al.(3) This finding, together with abnormalities in serum flocculation test results(4) indicated that the disease might be related to a long-continued autoimmune reaction