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When tirzepatide activates GLP-1 receptors, it stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite through central pathways in the hypothalamus

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Diagnostic translation has likewise been advanced by mitochondria-targeted probes: the 5MEF fluorescent probe demonstrates how mitochondrial accumulation and selective signal enhancement enable earlier, organelle-level detection of pathology

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