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Although a direct pharmacological link between retatrutide and B12 deficiency has not been confirmed, mechanistic parallels with approved GLP-1 medicines combined with the risk of prolonged dietary restriction make proactive nutritional monitoring a prudent and clinically responsible approach

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Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination