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Underlying Medical Conditions Thyroid disorders, hormonal imbalances, chronic inflammation, and sleep apnea can reduce the bodys responsiveness to weight loss interventions, even when using GLP-1 drugs

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The nose-to-brain pathway bypasses the blood-brain barrier through direct transport along olfactory and trigeminal nerve fibers

According to the Wegovy SmPC, while semaglutide delays gastric emptying, clinical pharmacology trials have shown no clinically relevant effect on the absorption of tested oral medicines