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Tirzepatide has demonstrated even greater efficacy in lowering HbA1c and achieving weight loss in clinical trials
Taking it during high-cortisol hours potentiates lipolytic signaling, while dosing during the GH pulse window shifts the metabolic balance toward protein synthesis and tissue repair
Similarly, once-a-day Saxenda (liraglutide) over 56 weeks led to an average of 8% weight loss, with 63% of participants experiencing clinically significant weight loss
Real 1:1 support changes behavior
That said, Wegovy is FDA-approved and widely prescribed for weight loss with excellent clinical responses, while retatrutide is still an investigational drug only available through clinical trials and its long-term safety and tolerability are still being studied
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