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The United States remains the reference market for the category

So they may lose weight initially, but then they plateau, feel worse, or regain the weight when they stop." Another issue is that GLP-1 medications can cause muscle loss and a drop in metabolic rate, which may make long-term weight maintenance more difficult

Despite its rarity, lipodystrophy represents a serious medical issue because it can interfere with drug uptake while also causing aesthetic problems [45]

For semaglutide, the typical starting dose is 0.25 mg weekly, increasing to 0.5 mg, then 1.0 mg, and potentially 2.4 mg over several months

Eur J Pharmacol 858:172443