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In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function

Accelerated aging, damaged or mutated cells, broken-down tissue, the activation of harmful genes within DNA, and an overloaded immune system

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

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Excessive ROS could damage the cellular components, leading to neuronal death