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Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VM, Birchmeier W, Fujita Y (2004) Rap1 regulates the formation of E-cadherin-based cell-cell contacts

doi: 10.1016/j.jaci.2010.11.001

Additionally, serine-derived metabolites such as glutathione, glycine, cysteine, and SAM support phase II metabolism because they are utilized for conjugation with toxins for toxin metabolism and excretion

Second, this agent can decompose the GSTJNK complex and promote activation of the apoptosis pathway

The resulted mtDNA damage will lead to mitochondrial dysfunction by affecting respiration activity and metabolism