Start your intake Absolute Contraindications: When GLP-1 Therapy Is Off Limits Certain medical histories completely disqualify patients from GLP-1 use
10.1002/ajmg.c.20007
Staying current on GLP-1 science Cognitive and brain support GLP-1s cross the bloodbrain barrier and are being studied for effects on neuroinflammation, mood, and cognitive resilience with promising early evidence for neuroprotection
Hepatocytes naturally process and eliminate metabolic waste products, medications, and environmental toxins through Phase I and Phase II biotransformation reactions
As for Polyphenol Booster, it contains: Pomegranate extract (375mg) , shown in a 2022 study to increase short-chain fatty acids and regulate GLP-1 secretion at 375mg doses,32 while a 2025 study found that pomegranate in general can help proliferate beneficial bacteria, including Akkermansia 33 Grape seed extract (275mg) , which produces a significant prebiotic effect on Akkermansia , as in a 2021 study that used 200mg doses34 Green tea extract (225mg) , which also favors Akkermansia proliferation,35 potentially at doses as low as around 50mg in a 150lb human (as suggested by mouse studies)36 All very well-dosed to support Pendulums probiotic supplements
