combination glp-1 and sglt2 Inhibitors Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Insights into the Roles of

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According to this, the first hit is induced by the accumulation of lipids in hepatocytes from high-caloric intake, obesity, insulin resistance, which makes the liver vulnerable to other damaging factors that are referred to as the second hits, such as oxidative stress, genetic polymorphisms (65)

Manchester et al

The following sections examine representative systemsapelin, spexin, meteorin-like protein (METRNL), and oxyntomodulinwith explicit attention to the evidence supporting their metabolic roles, the reasons for historical underexploration, and the translational questions that remain unresolved

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