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Semaglutide's long-term effects in obesity patients include sustained weight loss averaging 15-20% over two years, improved cardiovascular health markers, enhanced insulin sensitivity, and reduced inflammation levels

The clinical trials that showed disappointing results used oral administration

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Semaglutide for chronic weight management has been evaluated in clinical trials extending up to 68 weeks, with patients losing on the order of 15 percent of initial body weight , and semaglutide has been associated with up to roughly 16 percent weight loss over placebo

The dosage for each treatment is usually adjusted over time to find the level that provides the best results with the fewest side effects