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It also reduces the bodys production of lipoprotein lipase, an enzyme that breaks down fat in the blood, and can lead to insulin resistance, which increases the risk of weight gain and other metabolic issues, factors that can strain the heart
A key trial found that 600mg per day provided the best balance of effectiveness and tolerability, reducing instances of nausea, dizziness, and GI discomfort.4 A separate review of multiple studies supports this, concluding that 600mg daily is effective and well-tolerated for conditions like diabetic neuropathy, insulin resistance, and oxidative stress.5 That body of research has established 600mg of racemic ALA as a standard dose in clinical studies, thanks to its consistent balance of efficacy and tolerability
You get receptor desensitization and side effects that are entirely avoidable if you just start low and go slow
GLP-1 is a key and often life saving form of treatment in patients with diabetes or high heart disease risk