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Promote renal calcium reabsorption Renal tubular calcium transport: upregulate the expression of renal tubular calcium channel (TRPV5), reduce urinary calcium excretion by 30% -40%, increase blood calcium concentration, and increase bone calcium deposition Evidence from preclinical studies on AOD 9604 bone protection (animal experiments) Postmenopausal osteoporosis (OVX rat model) Experimental Design: Animal: 6-month-old female SD rats underwent bilateral ovariectomy (OVX) to establish a postmenopausal osteoporosis model
The answer is complex, but it is likely in large part due to the combination of its ubiquity in the body and the significant role it plays
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Key manifestations of mitochondrial dysfunction Mitochondrial dysfunction is typically triggered by pathological stresses such as genetic mutations and ischemia, or by the aging process [7], leading to decreased efficiency of the electron transport chain, which in turn causes excessive ROS production and reduced ATP synthesis [8]
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