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It is an ideal choice for those who prefer a refreshing drink with lemon ice tea flavour, instead of tablets or capsules

Jingjing Lv:original draft, writing review and editing, creation of figures/tables Yuanyuan Chen: Conceptualization, review & editing

(2025) T2DM: 47.3% reinitiated GLP-1 therapy within 1 year of discontinuation 57.3% reinitiated within 2 years Without T2DM: 36.3% reinitiated within 1 year 46.4% reinitiated within 2 years Key Factors Linked to Reinitiation: Patients age 65 years Less likely to reinitiate Weight regain after discontinuation Higher likelihood of restarting therapy Moderate to severe GI side effects during initial treatment Lower likelihood of reinitiation Main Takeaway: Most patients who initiated GLP-1 therapy stopped within one year, with higher discontinuation rates among those without T2DM

The rationale extends beyond simple formulation chemistry into the realm of NAD+ precursor biology, mitochondrial function, and adipose tissue metabolism

Concurrently, gluconic acid production triggers pH-responsive drug release (Wang et al., 2022)