The problem is absorption
Key points: Gastrointestinal side effects became more common as the dose rose in STEP UP, from 42.8% on placebo to 61.2% on 2.4 mg and 70.8% on 7.2 mg Altered skin sensations, such as tingling, were also more common on 7.2 mg (22.9%) than on 2.4 mg (6.0%) Nausea, diarrhoea, vomiting, and constipation are the most common side effects Side effects are usually worst just after a dose increase and often settle within a few weeks Its worth considering whether increasing the dose is worth the risk of increased side effects
In contrast, 13 C-MRS is very useful in monitoring the flow of labels from 13 C-labeled substrates to different neurotransmitters such as GABA, glutamate and aspartate, similar to that is used in the tracer approach to evaluate the functional status of tissues and organs (Figure 4)
If weight loss stalls for more than two weeks, reassess caloric intake, activity levels, and adherence
Market Value Forecast, by Detection Technique, 20172031 12.3.1