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At 85% relative humidity, folic acid decreases of 2122% at 25 C and 4049% at 40 C were found after 3 months of storage
With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]
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