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Currently, numerous natural products have been investigated as potential modulators of DOR, primarily in preclinical models (Supplementary Appendix 1)

In these conditions, the persistent activation of NADPH oxidase in microglia leads to continuous oxidative stress and damage ( The activation of phagocytic NADPH oxidase is a tightly controlled process that occurs in specific locations within the cell

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These effects create synergistic benefits that exceed what would be expected from simple addition of single-pathway therapies

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