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In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection using a gradual dose escalation schedule to minimise gastrointestinal side effects

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Thus, the search string that we applied is as follows: (GLP1 receptor agonists OR GLP-1 receptor agonists OR glucagon-like peptide-1 receptor agonists) AND (SGLT2 inhibitors OR SGLT-2 inhibitors OR sodium-glucose cotransporter 2 inhibitors) AND (Type 2 diabetes mellitus OR T2DM OR type 2 diabetes) AND (prevention OR delay OR onset) AND (efficacy OR effectiveness) AND (safety OR adverse effects) AND (patient characteristics OR age OR BMI OR comorbidities) AND (dosage OR dose OR treatment duration) AND (combination therapy OR synergistic effects)

The injection method is different based on which substance the bacteriostatic water is being mixed with

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