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FIGURE 5 Resveratrol Resveratrol is a natural antioxidant polyphenol that is rich in the roots of Reynoutria japonica Houtt

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Kynurenine, a metabolite of tryptophan, upregulates T-cell PD-1 levels by inducing and activating the aryl hydrocarbon receptor (AhR), while AhR upregulates transporters to promote T cells to uptake kynurenine, forming a positive feedback loop and inhibiting anti-tumor immune responses (Liu et al., 2018)