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Thus, for women with pre-existing diabetes in pregnancy, a post-delivery plan for reduced prepregnant insulin dosages, pump settings or noninsulin antihyperglycemic agents should be discussed with the woman and recorded before delivery

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For instance, a patient who is actively losing weight as they pass through the 42 or 43 BMI level may still be considered for surgery

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52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide

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