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In postmarketing studies, addiction, abuse, misuse, and fatal and non-fatal opioid overdose were observed in patients with long-term opioid use (see ADVERSE REACTIONS)

These reactions can compromise patient safety and limit the clinical applicability of these treatments

10.1016/j.jaac.2010.05.005 95

2017May;31(12):4085109

The activation of NF-B is integral to the processes associated with atherosclerosis, as it influences endothelial dysfunction and facilitates the production of adhesion molecules [167, 168]