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There is one more critical piece to know about both of these hormones: they are broken down by an enzyme called dipeptidyl peptidase-4, or DPP-4

Plus, since just 5% to 7% of body weight loss can help prevent prediabetes too, GLP-1 medications are helpful across the whole spectrumfrom diabetes prevention to management

Pancreatitis and Pancreatic Cancer: Debates and lawsuits center around the drug potentially raising pancreatitis risks, with caution also regarding long-term pancreatic cancer risks, especially in those with additional risk factors

EMBO Mol Med

The similar viewpoints were also supported by other critical reviews and clinical trials (58), and inferred that GLP-1RA could be considered in patients at a high risk of, or with established cardiovascular diseases to improve the prognosis of cardiovascular events (especially nonfatal stroke), whilst SGLT2i could be recommended for patients with heart failure or chronic kidney diseases