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Within the cytosol the accumulating fumarate, similar to the effect of accumulating succinate, results in the inhibition of 2-oxoglutarate and Fe 2+ -dependent dioxygenases that are responsible for the hydroxylation of the -subunit (HIF1) of the HIF-1 complex
Die Dosierung sollte individuell an das Krpergewicht angepasst werden, um optimale Ergebnisse zu erzielen
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Neurology 1995;45:2015-2017
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