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While HFpEF risk factors can independently contribute to HF and MF, the interplay of multiple comorbidities and their impact on fibrosis progression and treatment efficacy remain poorly understood (Mall et al., 1990

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In placebo-controlled adjunctive epilepsy trials in adults receiving topiramate 200 to 1,000 mg/day, hot flashes (1% to 2%), drug-induced body odor (0% to 1%), skin disorder (1% to 2%), hyperhidrosis (1% or less), and erythematous rash (1% or less) were reported with equal or greater frequency than placebo

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Plus, tirzepatide results in weight loss, including both fat mass and lean body mass