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In addition, pre-clinical studies highlighted that semaglutide is able to act on adipocytes and reduce visceral fat through the regulation of lipid uptake, lipid storage, and lipolysis in white adipose tissue

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We noted that for the purposes of the device pass-through evaluation process, CMS evaluates the nominated device that is the subject of an application to determine if the device meets the eligibility criteria described in 419.66

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This effect appears to be primarily achieved by promoting mitochondrial fatty acid -oxidation, as suggested by increased hepatic carnitine palmitoyltransferase-1 (CPT-1) activity, without significantly affecting lipogenesis

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