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We built models of HLI in GSDMD deficiency (Gsdmd -/- ) mice and their litters (WT)

The majority of ATP in the healthy heart is derived from mitochondrial oxidative metabolism, whereas the end-stage failing heart undergoes a drastic shift in energy metabolism

doi: 10.1016/j.cgh.2023.02.022

But as the use of GLP-1s has expanded, a subtler set of experiences has come into view

Several other factors, such as amino acids or tumor necrosis factor (TNF), are also implicated in the activation of mTORC1 and the promotion of IR [2,51]