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However, the latest 2025 update to the Obesity Canada pharmacotherapy guideline emphasizes that pharmacotherapy should be initiated only after a comprehensive assessment of adiposity and should be personalized according to individual values, preferences, and long-term adherence potential

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Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase

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By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects