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The CoQ 10 -mediated reaction also supplies orotate for the de novo pyrimidine synthesis through the oxidative activity of dihydroorotate dehydrogenase [44]

On the other hand, estrogens phenolic hydroxyl group can act as an anti-oxidant agent, being a protective factor against cardiovascular and neurodegenerative diseases (Kumar et al., 2010)

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CAF-conditioned medium inhibited the accumulation of doxorubicin, but not taxol, in prostate cancer cells in a manner that was associated with increased cancer cell glutathione levels

Nevertheless, the results reinforce confirming hypogonadism and reviewing cardiovascular risk with a clinician before starting testosterone therapy