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Larger and longer studies in broader populations are needed to fully understand the safety and efficacy in people with alcohol use disorder, but these initial findings are promising. Reference: Hendershot CS, Bremmer MP, Paladino MB, et al

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Joint discomfort may result from indirect factors such as rapid weight loss altering biomechanical loading, nutritional deficiencies from reduced caloric intake, changes in physical activity patterns, or coincidental conditions like osteoarthritis common in the patient demographic

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