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Molecular dynamics simulations Molecular dynamics simulations have been performed using the AMBER ff19SB force field 57 and the solvent molecules were represented as OPC water molecules 58

Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L, et al

Significantly, metformin has been demonstrated to normalize pulsatile GnRH secretion by reducing circulating insulin levels

Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKC in rat dorsal root ganglion neurons