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The presence of multiple amide and amine functionalities supports protonation under positive ion mode conditions

Actual dosing should always follow provider instructions

A 1:1 ratio is scientifically optimal. No clinically validated ratio was identified

Peptides are not inherently good or bad

Second, while we concurred that avoiding post-cystoscopy infections is important, we noted that none of the studies the applicant submitted as evidence evaluated or assessed the VersaVue [TM] Single-Use Flexible Cystoscope and that none of the studies compared clinical outcomes, such as adverse events (including post-cystoscopy infection) associated with the use of the VersaVue [TM] Single-Use Flexible Cystoscope to clinical outcomes associated with reusable cystoscopes