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GLP-1(2836) is a small peptide that targets novel molecular (MTP and sAC) and cellular (caSMC and caEC) mechanisms in myocardial ischemic injury

To probe whether semaglutide exerts a direct adverse vascular effect, a separate randomized controlled trial specifically investigated its impact on retinal physiology

They lower blood glucose levels, slow gastric emptying, lower serum cholesterol and triglyceride levels, reduce liver fat content, decrease the highly inflammatory visceral fat, enhance microvascular (!) blood flows in the muscle tissue, reduce muscle-produced inflammation, microglial activation (neuroinflammation), and enhance neuroplasticity

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Earlier in the year, Fractyl Health raised approximately $110 million to fund a GLP-1 gene therapy