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The amidated C-terminal residue differs across CT-family peptides and this residue forms the only direct contact with RAMPs in previously reported AMYR complexes 15,16

FDA will post its own background review of each substance at least two business days before the meeting

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Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study