For example, the minimally invasive needle IVD puncture procedure in rats aimed to model CDLBP, demonstrated that these animals developed pain based on a reduction of distance covered in the open field testing, inhibited rearing positions and twitching as compared to control sham animals
Morimura N, Yasuda H, Yamaguchi K, Katayama KI, Hatayama M, Tomioka NH, et al
Generally well tolerated, but dosing should be vet-guided especially with medications or chronic disease
Systemic Considerations (Experimental Observations Only) Some preclinical investigations report changes in: inflammatory markers oxidative stress pathways vascular responses However, these findings are model-dependent and do not define a consistent systemic safety profile
Each of these multiple reactions require a specific enzyme, thus conversion is a complex process, even for a healthy person