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Transcriptional responses to Cys depletion To gain insights into the molecular responses triggered by cysteine deprivation, we conducted bulk RNA-sequencing (RNA-seq) analysis of liver (which exhibits the highest expression of Cse ), muscle (the most abundant tissue) and adipose tissue (the tissue most impacted by cysteine loss)

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On the other hand, ARID2 (a subunit of PBAF) in SMARCB1-rescued cells (+ SMARCB1) localized only to the region proximal from the TSS of the SLC7A11 locus (Fig

These may support memory, attention, and mental clarity