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Patients should seek medical advice whenever therapy is stopped or restarted to ensure safe dosing and appropriate alternatives

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

whether AGEs directly induce ferroptosis via iron overload or lipid peroxidation, or indirectly by suppressing Nrf2/Sirtuin pathways, requires definitive validation

Polymer-based materials such as PEGylated or zwitterionic excipients have been explored to improve mucus penetration by reducing adhesive interactions, but these approaches remain largely experimental with minimal translation to oral peptide formulations (Zhu et al., 2021)