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Other studies, however, failed to find an association between the GPx-1 Pro198Leu polymorphisms and risk of breast cancer, including one study in a Canadian population (201), one from the United Kingdom (SEARCH) (55) and two studies from the United States (4, 79), including a study from the large prospective Nurses Health Study and a large casecontrol study, the Long Island Breast Cancer Study (79)

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