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Discussion It is well acknowledged that high dose and long term use of NSAIDs are associated with adverse effects that include cardiac, gastrointestinal, renal and hepatotoxicity 32,33

Step 1: Convert units 5 mg = 5,000 mcg 2 mL = 200 syringe units (since 1 mL = 100 units) Step 2: Calculate strength per syringe unit Strength per Unit= 5,000 mcg 200 units = 25 mcg per unit Step 3: Calculate syringe draw volume for target dose Syringe Pull (units)=250 mcg 25 mcg = 10 units Result: Draw your U-100 insulin syringe to the 10-unit mark to obtain a 250 mcg dose

Ann Thorac Surg 114(5):1895-1901, 2022