Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes (where deficiencies in the release or response to counter regulatory hormones exist), with autonomic neuropathy, intensified diabetes control, or taking beta-blockers, guanethidine, or reserpine
This contrasts with some single-pathway therapies that may show diminishing returns over time due to physiological adaptation or disease progression
Advanced Drug Delivery Reviews, 60 (13-14), 1463-1470
All analyses were performed using STATA 17.0 (StataCorp LLC, College Station, TX, USA)
Any use would be based on a thorough evaluation of the patient's condition, goals, and overall treatment plan." However, the evidence supporting BPC-157 remains limited