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FIGURE 4 Berberine nanoparticles improve the hepatic antioxidant capacity in the GDM rats To determine the impact of berberine nanoparticles on the antioxidant status in GDM rats, the concentration of GSH and the activity of antioxidant enzymes GPx, CAT, and SOD were measured in hepatic tissues at the end of the study

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Strikingly, substitution of proline at position 3 (P3A) abolished binding, yielding a KD = 56.7 (Fig