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85 Studies included in this review also evaluated several non-GLP-1 receptor agonists, including orlistat (8 studies), lorcaserin, phentermine, metformin, and naltrexone/bupropion aligning with their reported use in literature from Arab countries

In December 2007, after Phase 3 clinical trials Takeda Pharmaceuticals submitted alogliptin for approval

Secondary signals across both trials reduced knee osteoarthritis pain, fewer obstructive sleep apnea events, improvements in triglycerides, blood pressure, LDL, and hsCRP suggest systemic metabolic remodeling rather than simple caloric suppression

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CurrPharm Des 19 (1), 7683