doi: 10.1067/mjd.2003.274
By slowing cholesterol production, they lower LDL cholesterol levels in the bloodstream
Coronary effluents of isolated mouse hearts perfused with GLP-1(2836) showed a modest increase in extracellular cAMP levels that did not differ from levels in controls (Figure 2B)
In an oral cancer cell line, quercetin induced apoptosis and reversed drug resistance to vincristine (Oncovin) (Yuan 2015)
Still unlicensed in humans outside of research investor.lilly.com/news-releases/ TRIUMPH-1: #retatrutide topline data Phase 3, n=2,339, 80 wk, obesity without diabetes (efficacy estimand): 12 mg: -28.3% body weight (-31.9 kg) 9 mg: -25.9% | 4 mg: -19.0% | Placebo: -2.2% 30% weight loss: 45.3% vs 0.5% 104-wk extension (BMI 35, n=532), 12 mg MTD: -30.3% Cross-trial context (obesity, no diabetes): STEP-1 SEMA 2.4 mg, 68 wk: -14.9% SURMOUNT-1 TZP 15 mg, 72 wk: -20.9% TRIUMPH-1 RETA 12 mg, 80 wk: -28.3% But: Topline press release