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Strengths and limitations While causal relationships between GLP-1 RAs and NAEs remain unproven and underlying mechanisms remain uncertain, the temporal association observed in our analysis necessitates enhanced clinical vigilance for early detection and management

Excessive muscle loss can impair strength, mobility, and metabolic health

Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

The mechanism of action of GLP-1 might benefit pregnant women by providing adequate glycemic control, while minimizing insulin resistance, which is often exacerbated during pregnancy due to hormonal changes

GHK-Cus intermediate affinity is the feature that lets it act as a shuttle rather than a sink or a source of free radicals