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Acute toxicity studies have failed to establish a lethal dose even at very high concentrations in rodents, a finding reported by the Sikiric group and referenced in several reviews

The trade-off is that a vial with a larger volume takes up more space and is used up faster

Faster recovery may help athletes maintain training volume

Overdosing can lead to elevated B12 levels and potential side effects, while underdosing may not adequately address symptoms