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Preclinical studies suggest ALA may help defend neurons against oxidative stress, support synaptic function, and maintain healthy levels of glutathione, a critical antioxidant in brain cells.12 25 Importantly, ALA can cross the blood-brain barrier, making it a promising candidate for addressing conditions where oxidative stress or mitochondrial dysfunction play a role

This work was financially supported by the Jinhua Municipal Central Hospital Young and Middle-aged Scientific Research Start-up Fund (JY2022-2-11)

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Treatment of Drosophila flies with kynurenine pathway inhibitors and the NAD + precursors NR or NAM increased the lifespan of these animals, suggesting an advantage in combining different therapeutic strategies

doi: 10.1016/j.brainresbull.2020.11.008 37 ShanYTanSLinYLiaoSZhangBChenXet al