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The exclusion criteria for this review would be all secondary literature and any original articles written and submitted in languages other than English

Rather than asking how long you should stay on a dose, the more clinically relevant question is: what biomarkers and individual factors should guide your provider's recommendation for continuity, adjustment, or transition

Yes, glutathione supplements can cause constipation in 2550% of users taking oral reduced L-glutathione at doses above 500mg daily