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Rarely, hypersensitivity reactions can occur, for instance, urticaria (hives) or other allergic-type reactions have been reported in isolated cases

True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine

It said that Vitamin B12 deficiency is common among older adults and can have significant health implications if left untreated. Patients with Neurological Manifestations Those with neurological symptoms from B12 deficiency need special care

[44] Maternal vitamin B12 deficiency during pregnancy can lead to neural tube defects, impaired brain development, preterm birth, and low birth weight

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