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Vitamin B12 deficiency is common amongst older adults who do not have enough hydrochloric acid in their stomach to absorb Vitamin B12 naturally, individuals who take stomach acid-altering medications or antibiotics frequently, individuals who have a gastrointestinal conditions, vegetarians/ vegans, and individuals with pernicious anemia

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By May 1921 Banting and Best had sufficient quantities of insulin to begin testing it in dogs with well-established diabetes

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