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Increased risk of cholelithiasis was explained by Shaddinger et al

In infancy and early childhood, melanin in the iris can increase, which is why many babies are born with lighter eyes that darken over the first years of life

doi:10.1093/jexbot/51.348.1299 Patterson BD, Mac Rae EA, Ferguson IB 1984: Estimation of hydrogen peroxide in plant extracts using titanium (IV)

Marangella M, Vitale C, Bagnis C, Petrarulo M, Tricerri A

Given the negative results of other laboratory tests, Hashimotos thyroiditis, a primary organ-specific autoimmune disease associated with positive ANA, may be the underlying cause of the patients positive ANA test