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At doses of up to 30 micrograms per kilogram (g/kg), researchers noted that CJC-1295 DAC caused the following side effects: Mild injection site reactions Itching Headaches Pain Diarrhea Hypertension Induration The studys authors noted that around 70 percent of the test subjects who received CJC-1295 DAC experienced one or more of these side effects and that the severity of the reactions increased with doses over 30 g/kg

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The fatigue associated with GLP-1 compounds appeared in retatrutide trials as well, likely related to reduced caloric intake during the adaptation phase

While they are convenient, their effectiveness is limited by the digestive breakdown mentioned earlier